Twisting the Dragon's Tail: A Voyage into Uncharted Histone Territories
Centromeres can be used as a model for epigenetic regulation in normal and diseased states. Here the research focus is especially on non-canonical histone variants such as Centromer Protein A (CENP-A). In recent years, observations were made by the group led by Yamini Dalal, which succeeded in linking CENP-A and long non-coding RNAs (lncRNAs) originating from human centromeres to the maintenance of chromatin structure at the centromere, and dysregulation of chromatin structure in human tumors.
Yamini Dalal ist Gruppenleiterin im Labor von Gordon L. Hager (Receptor Biology and Gene Expression) am National Cancer Institute in Bethesda, USA, und derzeit Visiting Fellow am CAS.